Tweaking muscle metabolism prevents obesity and diabetes in mice

Tweaking muscle metabolism prevents obesity and diabetes in mice

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Mildly stressing muscle metabolism boosts levels of a beneficial hormone that prevents obesity and diabetes in mice, according to a new University of Iowa study. The findings, published in the EMBO Journal, show that triggering ER stress in mouse muscle cells causes them to produce and secrete significant amounts of the anti-diabetic hormone fibroblast growth factor-21 (FGF21), which then has widespread beneficial effects on whole-body metabolism.



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June 28, 2017 at 12:06PM

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